Puberty and polycystic ovary syndrome.
نویسنده
چکیده
Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder characterized by chronic anovulation and hyperandrogenism. This multi-system, polygenic, multi-factorial disorder is associated with an increased risk for metabolic abnormalities such as type 2 diabetes mellitus. Signs and symptoms of PCOS often emerge during the peri-pubertal years with premature pubarche (PP) being the earliest manifestation for some girls. Insulin resistance and hyperinsulinemia are important pathophysiological features that are common to both PP and PCOS. Future investigations are needed to uncover the relevant genetic and hormonal factors and identify effective interventions.
منابع مشابه
The Evolutionary Approach for Diagnostic Criteria of Polycystic Ovary Syndrome in Adolescents: a Review
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; text-align: justify; font: 12.0px 'Times New Roman'} span.s1 {text-decoration: underline} span.s2 {font: 11.0px Helvetica} Introduction: Polycystic ovary syndrome (PCOS) in adults is diagnosed based on clinical, biochemical, and radiological criteria, although in adolescents, some of these criteria may overlap with the normal process of puberty, which ...
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ورودعنوان ژورنال:
- Molecular and cellular endocrinology
دوره 254-255 شماره
صفحات -
تاریخ انتشار 2006